Therefore God also gave them up to uncleanness, in the lusts of their hearts, to dishonor their bodies among themselves,

Spiritual judgments are of all judgments the sorest, and to be most dreaded.

Observe,

By whom they were given up.

God gave them up; in a way of righteous judgment, as the just punishment of their idolatry - taking off the bridle of restraining grace - leaving them to themselves - letting them alone.

Whether this giving up be a positive act of God or only privative we leave to the schools to dispute: but this we are sure of that it is no new thing for God to give men up to their own hearts’ lusts, to send them strong delusions, to let Satan loose upon them, nay, to lay stumbling-blocks before them.

And yet God is not the author of sin, but herein infinitely just and holy; for, though the greatest wickedness follow upon this giving up, the fault of that is to be laid upon the sinner’s wicked heart.

If the patient be obstinate, and will not submit to the methods prescribed, but willfully takes and does that which is prejudicial to him, the physician is not to be blamed if he give him up as in a desperate condition; and all the fatal symptoms that follow are not to be imputed to the physician, but to the disease itself and to the folly and willfulness of the patient.

http://www.biblegateway.com/passage/?search=romans%201&version=NKJV